The Reineke Group was featured on KARE11 News for their recently published research article, entitled “High-Throughput Excipient Discovery Enables Oral Delivery of Poorly Soluble Pharmaceuticals”, in ACS Central Science, a leading chemistry journal. In the research article, the authors describe the development of a high-throughput methodology for the preparation of polymeric excipients, inactive ingredients that improve the solubility, bioavailability, and safety of drug formulations. This methodology will allow companies to create customized excipients that have the potential to revive a large number of promising drug pipeline candidates that would typically have been rejected due to solubility concerns. Therefore, this methodology could also serve to reduce the R&D expenditures and time necessary for companies to bring drugs to the market.
This project is a collaboration with The Dow Chemical Company and Professor Bates’ research group in the Department of Chemical Engineering and Materials Science. Reineke Group alumnus Jeff Ting was the first author of this study.
The KARE11 News story is available online (link) and the research article can be accessed on the ACS Central Science website (link). The University of Minnesota College of Science & Engineering also covered this research study (link).