Joseph Hexum

Research Professional


M.S. Environmental Health Sciences, Concentration in Industrial Hygiene
University of Minnesota - Twin Cities

B.S. Chemistry
Hamline University


Ingle, N. P.; Hexum, J. K.; Reineke, T. M. "Polyplexes Are Endocytosed By and Trafficked Within Filopodia", Biomacromolecules 2020, Article ASAP.

Van Bruggen, C.; Hexum, J. K.; Tan, Z.; Dalal, R. J.; Reineke, T. M. Nonviral Gene Delivery with Cationic Glycopolymers, Acc. Chem. Res. 2019, 52, 1347–1358.

Phillips, H. R.; Tolstyka, Z. P.; Hall, B. C.; Hexum, J. K.; Hackett, P. B.; Reineke, T. M. Glycopolycation-DNA Polyplex Formulation N/P Ratio Affects Stability, Hemocompatibility, and In Vivo Biodistribution, Biomacromolecules 2019, 20, 1530–1544.

Zhang, Q.; Phillips, H. R.; Purchel, A.; Hexum, J. K.; Reineke, T. M. Sustainable and Degradable Epoxy Resins from Trehalose, Cyclodextrin, and Soybean Oil Yield Tunable Mechanical Performance and Cell Adhesion, ACS Sustainable Chem. Eng. 2018, 6, 14967–14978.

Kerr, J. P.; Robinson, P.; Shi, G.; Bogush, A. I.; Kempema, A. M.; Hexum, J. K.; Becerra, N.; Harki, D. A.; Martin, S. S.; Ratieri, R.; Prosser, B. L.; Ward, C. W. Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle. Nat. Commun. 2015, 6, 8526.

Kempema, A. M.; Widen, J. C.; Hexum, J. K.; Andrews, T. W.; Wang, D.; Rathe, S. K.; Meece, F. A.; Noble, K.; Sachs, Z.; Largaespada, D. A.; Harki, D. A. Synthesis and antileukemic activities of C1-C10 modified parthenolide analogues. Bioorg. Med. Chem. 2015, 23, 4737–4745.

Hexum, J. K.; Becker, C. M.; Kempema, A. M.; Ohlfest, J. R.; Largaespada, D. A.; Harki, D. A. Parthenolide prodrug LC-1 slows growth of intracranial glioma. Bioorg. Med. Chem. Lett. 2015, 25, 2493–2495.

Wen B.; Hexum, J. K.; Widen, J. C.; Harki, D. A.; Brummond, K. M. A redox economical synthesis of bioactive 6,12-guaianolides. Org. Lett. 2013, 15, 2644–2647.

Hexum, J. K.; Tello-Aburto, R.; Struntz, N. B.; Harned, A. M.; Harki, D. A. Bicyclic cyclohexenones as inhibitors of NF-kappaB signaling. ACS Med. Chem. Lett. 2012, 3, 459–464.